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Faculté de médecine dentaire
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Moldovan, Florina


M.D., Ph. D.

Coordonnées

T : 514 345-4931 # 5746
F : 514 345-4801
florina.moldovan@umontreal.ca

Adresse géographique

CHU Sainte-Justine
Centre de Recherche
3175, Chemin de la Côte Sainte-Catherine
Montréal (QC), Canada  H3T 1C5

Adresse postale

Faculté de médecine dentaire
Université de Montréal
C.P. 6128, succ. Centre-ville
Montréal (Québec)  H3C 3J7

Fonctions

  • Professeure titulaire, département de stomatologie
  • Chercheuse, Centre de recherche, CHU Sainte-Justine
  • Directrice du Laboratoire de biologie moléculaire orthopédique

Champs d’intérêt

Arthrose-arthrite, biologie cellulaire, cytokines, endothélium, endothéline, hybridation in situ, immunoanalyse, immunohistochimie, métalloprotéases, récepteurs membranaires, scoliose idiopathique de l'adolescence.

Formation

  • 1986 – Doctorat en médecine, Université de Belgrade, Yougoslavie
  • Endocrinologie – Métabolisme, Université Pierre et Marie Curie de Paris VI, France
  • 1991 – DEA de biotechnologie, Université Pierre et Marie Curie de Paris VI, France
  • 1995 – Ph. D. en biochimie, Université René Descartes, Paris V, France

Prix et disctinctions

  • 2014 – Récipiendaire du prix « GRAMMER European Spine Journal Award 2015  » pour le meilleur article de science fondamentale intitulé « Microarray expression profilling identifies genes with altered expression in Adolescent Idiopathic Scoliosis » publié dans l’European Spine Journal au cours de l’année académique 2013-2014.
  • 2012 – Lauréat de la Fondation Yves Cotrel – Institut de France. Projet: Validation de deux gènes mutés chez les patients atteints de la SIA et des contrôles, par séquençage, étude fonctionnelle utilisant le modèle cellulaire et l’approche morpholino chez le poisson zébre.
  • 2012 – Lauréat de la Fondation Yves Cotrel – Institut de France. Projet: Pathogénèse de la scoliose idiopathique en tant que combinaison de croissance, ostéopénie et bipédalité

Publications sélectionnées

Patten SA, Margaritte-Jeannin P, Bernard JC, Alix E, Labalme A, Besson A, Girard SL, Fendri K, Fraisse N, Biot B, Poizat C, Campan-Fournier A, Abelin-Genevois K, Cunin V, Zaouter C, Liao M, Lamy R, Lesca G, Menassa R, Marcaillou C, Letexier M, Sanlaville D, Berard J, Rouleau GA, Clerget-Darpoux F, Drapeau P, Moldovan F, Edery P. Functional variants of POC5 identified in patients with idiopathic scoliosis. J Clin Invest. 2015 Mar 2;125(3):1124-8. doi: 10.1172/JCI77262. Epub 2015 Feb 2

Shi Q, Abusarah J, Zaouter C, Moldovan F, Fernandes JC, Fahmi H, Benderdou M. New evidence implicating 4-hydroxynonenal in the pathogenesis of osteoarthritis in vivo. Arthritis Rheumatol. 2014 May 16.

Ménard AL, Grimard G, Valteau B, Londono I, Moldovan F, Villemure I.In vivo dynamic loading reduces bone growth without histomorphometric changes of the growth plate.J Orthop Res. 2014 Sep;32(9):1129-36. doi: 10.1002/jor.22664. Epub 2014 Jun 6.

Londono D, Kou I, Johnson TA, Sharma S, Ogura Y, Tsunoda T, Takahashi A, Matsumoto M, Herring JA, Lam TP, Wang X, Tam EM, Song YQ, Fan YH, Chan D, Cheah KS, Qiu X, Jiang H, Huang D; Japanese Scoliosis Clinical Research Group, TSRHC IS Clinical Group, the International Consortium for Scoliosis Genetics (including Moldovan F), Su P, Sham P, Cheung KM, Luk KD, Gordon D, Qiu Y, Cheng J, Tang N, Ikegawa S, Wise CA. A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. Med Genet. 2014 Jun;51(6):401-6.

Feldman DE, Beausejour M, Sosa JF, Goulet L, Parent S, Labelle H and the members of the Québec Scoliosis Society and the Canadian Pediatric Spinal Deformities Group. Cost effectiveness of school screening for scoliosis: A systematic review. Int J Child Adolesc Health 2014:7(1):1-7.

Beausejour M, Goulet L, Parent S, Feldman DE, Turgeon I, Roy-Beaudry M, Sosa JF, Labelle H and Members of the Québec Scoliosis Society and of the Canadian Paediatric Spinal Deformities Study Group (including Moldovan F). The effectiveness of scoliosis screening programs: methods for systematic review and expert panel recommendations formulation. Scoliosis 2013 Jul 24;8(1):12.

Fendri K, Patten SA, Kaufman GN, Zaouter C, Parent S, Grimard G, Edery P, Moldovan F. Microarray expression profiling identifies genes with altered expression in Adolescent Idiopathic Scoliosis. Eur Spine J. 2013 Jun;22(6):1300-11. doi: 10.1007/s00586-013-2728-2.

Moldovan F, Villemure I, Fendri K, Grimard G, Zaouter C, Parent S, Moreau A, Labelle H, Patten SA. Adolescent Idiopathic Scoliosis (AIS): Metabolic Factors, Biomechanical Stress and Estrogen Impact. Stud Health Technol Inform. 2012;176:452

Moldovan F, Patten SA, Fendri K, Girard S, Zaouter C, Edery P. Exome sequencing identifies novel candidate mutations in idiopathic. Stud Health Technol Inform. 2012; 176:453.

Menard AL, Valteau B, Londono I, Moldovan F, Grimard G, Villemure I. Influence of dynamic loading parameters on bone growth modulation. Stud Health Technol Inform. 2012; 176:469.

Bentz M, Zaouter C, Shi Q, Fahmi H, Moldovan F, Fernandes JC, Benderdour M. Inhibition of inducible nitric oxide synthase prevents lipid peroxidation in osteoarthritic chondrocytes. J. Cell. Biochem. 2012. Jul; 113(7):2256-67.

Feldman DE, Beausejour M, Sosa JF, Goulet L, Parent S, Labelle H and the members of the Québec Scoliosis Society and the Canadian Pediatric Spinal Deformities Group. Cost effectiveness of school screening for scoliosis: A systematic review. Int J Child Adolesc Health 2014:7(1):1-7.

Moldovan F, Villemure I, Fendri K, Grimard G, Zaouter C, Parent S, Moreau A, Labelle H, Patten SA. Adolescent Idiopathic Scoliosis (AIS): Metabolic Factors, Biomechanical Stress and Estrogen Impact. Stud Health Technol Inform. 2012;176:452

Moldovan F, Patten SA, Fendri K, Girard S, Zaouter C, Edery P. Exome sequencing identifies novel candidate mutations in idiopathic. Stud Health Technol Inform. 2012; 176:453.

Patten S, Jacobs NL, Zaouter C, Drapeau P, Albertson CR, Moldovan F. Novel Role of Chd7 in retinal organization and vertebral mineralization in a zebrafish model of charge syndrome. PLoS One. 2012; 7(2):e31650. Epub 2012 Feb 20

Acaroglu E, Moldovan F, Moreau A, Marcucio R, Enouf J, Bobe R. The metabolic basis of Adolescent Idiopathic Scoliosis 2011 report of the metabolic workgroup of the Foundation Yves Cotrel. Eur Spine J. 2012 Mar 9. [Epub ahead of print].

Valteau B, Grimard G, Londono I, Moldovan F, Villemure I. In Vivo dynamic bone growth modulation is less detrimental but as effective as static growth modulation, Bone. 2011 Nov; 49(5):996-1004.

Kaufman GN, Zaouter C, Valteau B, Sirois P, Moldovan F. Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology in a surgical model of osteoarthritis, Arthritis & Res Therapy, 2011 May 16;13(3):R76.

Edery P, Margaritte-Jeannin P, Biot B, Labalme A, Bernard JC, Chastang J, Kassai B, Plays MH, Moldovan F, Clerget-Darpoux F. New disease gene location and high genetic heterogeneity in Idiopathic Scoliosis. Eur J Hum Genet. 2011 Aug; 19(8):865-9.

Fendri K, Moldovan F. Potential role of COMP as a biomarker for idiopathic scoliosis. Med Hypotheses, 2011 May;76(5):762-3.

 Patten S, Moldovan F. Could genetic determinants of inner ear anomalies be a factor for the development of idiopathic scoliosisis? Med Hypotheses. 2011 Mar; 76(3) :438-40.

Sergerie K, Parent S, Londono I, Moldovan F, Villemure I. Growth plate explants respond differently to in vitro static and dynamic loadings.J Orthop Res. 2011 Apr;29(4) :473-80

Leboeuf D, Letellier K, Alos N, Edery P, Moldovan F. Do estrogens impact adolescent idiopathic scoliosis? Trends in Endocrinology and Metabolism (IF 7.1) 2009 Apr 4. [Epub ahead of print]

Cancel, M., Grimard, G., Thuillard-Crisinel, D., Moldovan F. & Villemure, I. (2009) Effects of in vivo static compressive loading on aggrecan and type II and X collagens in the rat growth plate extracellular matrix. Bone, 44(2), 306-15. Epub 2008 Sep 24.

Quintero, M., Riera, H., Colantuoni, G., Khatib, A. M., Attalah HL, Moldovan F, Mitrovic, D. R. & Lomri, A. (2008) Granulocyte-macrophage colony stimulating factor is anabolic and interleukin-1beta is catabolic for rat articular chondrocytes. Cytokine. 2008 Dec;44(3):366-72. Epub 2008 Nov 20.

Letellier K, Azeddine, B., Parent, S., Labelle, H., Rompre, P. H., Moreau, A. & Moldovan F. (2008) Estrogen cross-talk with the melatonin signaling pathway in human osteoblasts derived from adolescent idiopathic scoliosis patients. J Pineal Res, 45(4), 383-93. Epub 2008 May 26.

Letellier K, Azeddine B, Blain S, Turgeon I, Wang DS, Samba Boiro M, Moldovan F, Labelle H, Poitras B, Rivard C-H, Grimard G, Parent S, Ouellet J, Lacroix G, and Moreau A. Récents progrès dans l’étiopathogenèse de la scoliose idiopathique de l’adolescent et nouveaux concepts moléculaires. Médecine/Sciences. 2007 Nov:23(11) :910-916.

Calin Lungu, Jenny  Pena Dias, Camilla Estevão de França, Brice Ongali,  Domenico Regoli, Moldovan F, Réjean Couture. Involvement of kinin B1 receptor and oxidative stress in sensory abnormalities and arterial hypertension in an experimental rat model of insulin resistance. Neuropeptides. 2007 Dec:41(6):375-87

Khatib AM, Lomri A, Mitrovic RD, Moldovan F. Articular chondrocyte aging and endothelin-1. Articular chondrocyte aging and endothelin-1. Cytokine. 2007 Jan;37(1):6-13.

Azeddine B, Letellier K, Wang DS, Moldovan F and Moreau A. Molecular determinants of melatonin signalling dysfunction in in Adolescent Idiopathic Scoliosis. Clin Orthop Relat Res. 2007 Jun 7

Picard C, Azeddine B, Moldovan F, Martel-Pelletier J, Fernandes J, and Moreau A. New Emerging Role of Pitx1 Transcription Factor in Osteoarthritis Pathogenesis. Clin Orthop Relat Res. 2007 May 31

Felx M, Guyot MC, Isler M, Turcotte RE, Doyon J, Khatib AM, Leclerc S, Moreau A, Moldovan F. Entotheline-1 (ET-1) promotes MMP-2 and MMP-9 induction involving transcription factor NF-kappaB in human osteosarcoma. Clin Sci (Lond) 2006, 110 (6): 645-654

Korban T, Landreville V,  Leclerc S, Kauzman A, Mason AM, Moreau A, F. Moldovan Osteoarthritic lesions in temporo-mandibular joints of STR/ort mice. Journal of the Canadian Dental Association (JCDA) , October 2006 Vol72, No 8, page 693

Lévesque M, Guimond JC, Pilote M, Leclerc S, Moldovan F, Roy S. Expression of heat-shock protein 70 during limb development and regeneration in the axolotl. Dev Dynamics 2005;  233(4): 1525-1534.

Manacu CA, Martel-Pelletier J, Pelletier J-P, Shipkolye F, Fernandes JC, Mitrovic DR, Moldovan F. Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and up-regulates collagenases production. Arthritis Research Therapy 7:R324-32, 2005.

Roy-Beaudry M, Martel-Pelletier J, Pelletier J-P, Nait M’Barek K, Christgau S, Shipkolye F, Moldovan F. Endothelin-1 promotes osteoarthritic cartilage degradation via MMP-1 and MMP-13 induction. Arthritis Rheum 48(10):2855-64.2003

Pelletier J-P, Fernandes JC, Moldovan F, Schrier D, Flory C, Martel-Pelletier J. In vivo inhibition of MEK1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes. Arthritis Rheum. 48(6):1582-93, 2003.

Boileau C, Martel-Pelletier J, Moldovan F, Jouzeau JY, Netter P, Manning PT,  Pelletier JP.  The in situ up-regulation of chondrocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxide. Arthritis Rheum. 2002, 46(10):2637-47.

Boileau C, Martel-Pelletier J, Jouzeau JY, Netter P, Moldovan F, Laufer S, Tries S, Pelletier JP.  Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors. J Rheumatol. 2002 Jul;29(7):1446-53.

Khatib AM, Siegfried G, Messai H, Moldovan F, Mitrovic DR.  Mechanism of inhibition of endothelin-1-stimulated proteoglycan and collagen synthesis in rat articular chondrocytes. Cytokine. 2002 Mar 7;17(5):254-61.

Moldovan F, Pelletier JP, Mineau F, Dupuis M, Cloutier JM, Martel-Pelletier J.  Modulation of collagenase 3 in human osteoarthritic cartilage by activation of extracellular transforming growth factor beta: role of furin convertase. Arthritis Rheum. 2000 Sep;43(9):2100-9.

Moldovan F, Pelletier JP, Jolicoeur FC, Cloutier JM, Martel-Pelletier J.  Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage. Osteoarthritis Cartilage. 2000 May;8(3):186-96.

Publications majeures avant 2000

Moldovan F, Martel-Pelletier J, Hambour J, Cloutier JM, Pelletier JP. Collagenase-3 (MMP13) is preferentially localized in the deeper layer of human arthritic cartilage. In vitro mimicking effect by TGF-beta. Arthritis & Rheum. 40: 1653-61, 1997.

Moldovan F, Bennani H, Fiet J, Cussenot O, Dumas J, Darbord C, Soliman HR. Establishment of permanent human endothelial cells achieved by transfection with SV40 large T antigen which retains typical phenotypic and functional characteristics. In vitro Cell. Dev. Biol. Anim. 32: 16-23, 1996.


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