Roy, Stéphane

Fonctions

• Professeur agrégé, Département de stomatologie, Faculté de médecine dentaire, Université de Montréal
• Professeur accrédité, Département de biochimie, Faculté de médecine, Université de Montréal
• Directeur du Laboratoire de recherche sur la régénération tissulaire chez les vertébrés
• Chercheur affilié centre de recherche de l’Hôpital du Sacré-Cœur
• Membre du Comité de Déontologie de l’Université de Montréal

Champs d’intérêt

Étude des mécanismes moléculaire et cellulaire essentiels pour la phase de préparation lors de la régénération épimorphique chez les vertébrés.

Publications sélectionnées

Publications depuis 2000

Roy S and Gatien S. Regeneration in axolotls: a model to aim for! Experimental Gerontology 43(11):968-973 2008

Ghosh S, Roy S, Séguin C, Bryant S & Gardiner D. An analysis of the expression and function of Wnt-5a and Wnt-5b in developing and regenerating axolotl (Ambystoma mexicanum) limbs. Development Growth and Differentiation 50(4):289-97 2008.

Lévesque M, Gatien S, Finnson K, Desmeules S, Villiard É, Pilote M, Philip A & Roy S. Transforming growth factor – β signaling is essential for limb regeneration in axolotls. PLoS One  11: e1227, 2007. Open access.

Villiard É, Brinkmann H, Moiseeva O, Malette FA, Ferbeyre G and Roy S. Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer. BMC Evolutionary Biology 7:180, 2007. Open access.

Hutchison C, Pilote M, Lévesque M, & Roy S. The axolotl limb: a model for bone development, regeneration and fracture healing. BONE 40(1):45-56, 2007. Cover article.

Roy S and Lévesque M. Limb regeneration in axolotl: is it superhealing? The Scientific World Journal 1 (S1): 12-25, 2006. Open access.

Finnson KW, Tam BYY, Marcoux A, Lepage P, Roy S, Liu K and Philip A. Identification of CD109 as a TGF-beta accessory receptor in human keratinocytes FASEB Journal 20: Jul;20(9):1525-7, 2006.

Lévesque M, Guimond JC, Pilote M, Leclerc S, Moldovan F and Roy S. Expression of Heat-shock protein 70 during limb development and regeneration in the axolotl. Developmental Dynamics 233 (4): 1524-1534, 2005.

Roy S & Gardiner DM. Cyclopamine induces digit loss in regenerating axolotl limbs. J. Experimental Zoology 293: 186-190, 2002.

Ghosh S, Roy S, Pfeifer A, Schmitt M, Verma IM, Bryant SV and Gardiner DM. Advances in functional analysis in urodele amphibians. Axolotl News Letter (Electronic publication) 29: 4-8, 2001.

Roy S, Gardiner DM, & Bryant SV. Vaccinia as a tool for functional analysis in regenerating limbs: Ectopic expression of Shh. Developmental Biology 218: 199-205, 2000. Cover article.

Publications majeures avant 2000

Gardiner DM,  Carlson MRJ, & Roy S. Towards a functional analysis of limb regeneration. Seminars in Cell and Developmental Biology (Review) 10: 385-393, 1999.

Tenenhouse HS, Roy S, Martel J & Gauthier C. Differential expression, abundance, and regulation of Na+-phosphate cotransporter genes in murine kidney. American J. Physiology 275: F527-534, 1998.

Roy S, Martel J, & Tenenhouse HS. Growth hormone normalizes renal 1,25-dihydroxyvitamin D3-24-hydroxylase gene expression but not Na+-phosphate cotransporter (Npt2) mRNA in phosphate-deprived Hyp mice. J Bone and Mineral Research 12: 1672-1680, 1997.

Roy S and Tenenhouse HS. Transcriptional regulation and renal localization of 1,25-dihydroxyvitamin D3-24-hydroxylase gene expression: Effects of the Hyp mutation and 1,25-dihydroxyvitamin D3. Endocrinology 137: 2938-2946, 1996.

Roy S, Martel J, & Tenenhouse HS. Comparative effects of 1,25-dihydroxyvitamin D3 and EB 1089 on mouse renal and intestinal 25-hydroxyvitamin D3-24-hydroxylase. J Bone and Mineral Research 10: 1951-1959, 1995.

Roy S, Martel J, Ma S, & Tenenhouse HS. Increased renal 25-hydroxyvitamin D3-24-hydroxylase messenger RNA and immunoreactive protein in phosphate-deprived Hyp mice: A mechanism for accelerated 1,25-dihydroxyvitamin D3 catabolism in X-linked hypophosphatemic rickets. Endocrinology 134: 1761-1767, 1994.

Tenenhouse HS, Werner A, Biber J, Ma S, Martel J, Roy S, & Murer H. Renal Na+-phosphate co-transport in murine X-linked hypophosphatemic rickets: Molecular characterization. J Clin Invest. 93:671-676, 1994.

Roy S, Martel J, Chahal O, & Tenenhouse HS. Comparative effects of 1,25-dihydroxyvitamin D3 and EB 1089 on murine 25-hydroxyvitamin D3-24-hydroxylase. Proceedings on the Ninth Workshop on Vitamin D: Vitamin D. A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications, edited by A.W. Norman, R. Bouillon, M. Thomasset; Walter de Gruyter, Berlin-New York, 1994, p. 157.