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Faculté de médecine dentaire
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Amzica, Florin

M. Sc., Ph. D.


T : 514 343-6111 # 3337
F : 514 343-2111

Adresse géographique

Faculté de médecine dentaire
Pav. Paul-G.-Desmarais, local 2124
2960, chemin de la Tour
Montréal (Qc)  H3T 1J4

Adresse postale

Faculté de médecine dentaire
Université de Montréal
C.P. 6128, succ. Centre-ville
Montréal (Québec)  H3C 3J7


  • Professeur agrégé
  • Directeur du Laboratoire de neurophysiologie du sommeil et des états de conscience altérés
  • Membre du groupe DBS neurochirurgie, CHUM
  • Membre de Society for Neuroscience, The American Physiology Society, American Epilepsy Society

Champs d’intérêt

  • Les mécanismes cellulaires du coma
  • Le dialogue neurone-glie
  • Les mécanismes de l’anesthésie
  • Les effets des implantations et stimulations électriques sur les patients Parkinson


  • 1999 – Postdoctorale, Université Laval, Neurophysiologie
  • 1995 – Ph. D.,  Université Laval, Neurobiologie
  • 1982 – Ingénieur, M.Sc. Institut Polytechnique de Bucarest, Informatique et automatisations

Publications sélectionnées

Publications depuis 2000

Kroeger D, Florea B and Amzica F. (2013) Novel activity patterns in the anesthesia-induced comatose brain: beyond the isoelectric line. PLOS ONE 8:e75257.

Ferron J-F, Kroeger D, Chever O. and Amzica F. (2009) Cortical inhibition during burst-suppression induced with isoflurane anesthesia. J. Neurosci. 29:9850-9860.

Khoury S, Chouchou F, Amzica F, Giguère J-F, Denis R, Rouleau GA, Lavigne GJ. (2013) Rapid EEG activity during sleep dominates in mild traumatic brain injury patients with acute pain. J. Neurotrauma 30:633-641.

Crisan M, Crisan D, Sannino G, Lupsor M, Badea R and Amzica F. (2013) Ultrasonographic staging of cutaneous malignant tumors: an ultrasonographic depth index. Arch. Dermatol. Res. 305:305-313.

Amzica F and Kroeger D. (2011) Cellular mechanisms underlying EEG waveforms during coma. Epilepsia Suppl. 8:25-27.

Dufour S, Dufour P, Chever O, Lavallé R and Amzica F. (2011) In vivo simultaneous intra- and extracellular potassium recordings using a micro-optrode. J.Neurosci.Meth. 194:206-217.

Amzica F. (2010) Comment on "The human K-complex represents an isolated cortical down-state". Science, 330:35.

Chever O, Djukic B, McCarthy K and Amzica F. (2010) Implication of Kir4.1 channel in excess potassium clearance: an in vivo study on anesthetized glial-conditional Kir4.1 knock-out mice. J. Neurosci. 30:15769-15777.

Kroeger D, Tamburri A, Amzica F and Sik A. (2010) Activity dependent layer-specific changes in the extracellular chloride concentration in the rat hippocampus. J. Neurohysiol. 103:1905-1914.

Amzica F. (2009) Basic physiology of burst-suppression. Epilepsia 50 (Suppl.12):38-39.

Amzica F. (2009) Spike-wave seizures: cortical or thalamic? Clin. Neurophys. 120:1999.

Talavera, J., Esser, S.K., Amzica, F., Hill, S., and Antognini, J.F. (2009) Modeling the GABAergic action of etomidate on the thalamocortical system. Anesth. & Analg. 108:160-167.

Tetrault, S., Chever, O., Sik, A. and Amzica, F. (2008) Opening of the blood-brain barrier during isoflurane anesthesia. J. Eur. Neurosci. 28:1330-1341.

Kroeger, D. and Amzica, F. (2007) Hypersensitivity of the comatose brain to subliminal mechanical stimulations. J. Neurosci., 27:10597-10607.

Seigneur, J., Kroeger, D., Nita, D.A. and Amzica, F. (2006) Cholinergic activation of cortical glial cells in vivo. Cereb. Cortex, 16:655-668.

Nuñez, A. and Amzica, F. (2004) Generation mechanisms of slow EEG waves during sleep (in Spanish). Revista de Neurologia, 39:628-633.

Nita, D.A., Vanhatalo, S., Lafortune, F.D., Voipio, J., Kaila, K. and Amzica, F. (2004) Origin of non-neuronal EEG signals: an in vivo study in the cat. J. Neurophysiol., 92:1011-1022.

Nita, D.A., Steriade, M. and Amzica, F. (2003) Hyperpolarisation rectification in cat lateral geniculate neurons modulated by intact corticothalamic projections. J. Physiol. (Lond.), 552:325-332.

Steriade, M. and Amzica, F. (2003) Sleep oscillations developing into seizures in corticothalamic systems. Epilepsia, 44:9-20.

Amzica, F. (2002) Physiology of sleep and wakefulness as it relates to the physiology of epilepsy. J. Clin. Neurophysiol., 19:488-503.

Amzica, F. (2002) In vivo electrophysiological evidences for cortical neuron-glia interactions during slow (<1 Hz) and paroxysmal sleep oscillations. J. Physiol. (Paris), 96:209-219.

Amzica, F. and Massimini, M. (2002) Glial and neuronal interactions during sleep and paroxysmal activities in the neocortex. Cereb. Cortex, 12: 1101-1113.

Amzica, F., Massimini, M. and Manfridi, A. (2002) Spatial buffering during slow and paroxysmal sleep oscillations in cortical networks of glial cells in vivo. J. Neurosci., 22: 1042-1053.

Amzica, F. and Steriade, M. (2002) The functional significance of K-complexes. Sleep Medicine Reviews, 6:139-149.

Massimini, M. and Amzica, F. (2001) Extracellular calcium fluctuations and intracellular potentials in the cortex during the slow sleep oscillation. J. Neurophysiol., 85: 1346-1350.

Amzica, F. and Steriade, M. (2000) Neuronal and glial membrane potentials during sleep and paroxysmal oscillations in the neocortex. J. Neurosci., 20: 6648-6665.

Amzica, F. and Steriade, M. (2000) Integration of low-frequency sleep oscillations in corticothalamic networks. Acta Neurbiol. Exp., 60:229-245.

Neckelmann, D., Amzica F. and Steriade, M. (2000) Changes in neuronal conductance during different components of cortically generated spike-wave seizures. Neuroscience, 96:475-485.

Publications majeures avant 2000

Steriade, M. and Amzica, F. (1999) An intracellular study of excitability in the seizure-prone neocortex in vivo. J. Neurophysiol., 82:3108-3122.

Amzica, F. and Steriade, M. (1999) Spontaneous and artificial activation of neocortical seizures. J. Neurophysiol., 82:3123-3138.

Neckelmann, D., Amzica, F. and Steriade, M. (1998) Spike-wave complexes and fast components of cortically generated seizures. III. Synchronizing mechanisms. J. Neurophysiol., 80:1480-1494.

Steriade, M., Amzica, F., Neckelmann, D. and Timofeev, I. (1998) Spike-wave complexes and fast components of cortically generated seizures. II. Extra- and intracellular patterns. J. Neurophysiol., 80:1456-1479.

Steriade, M. and Amzica, F. (1998) Slow sleep oscillations, rhythmic K-complexes, and their paroxysmal developments. J. Sleep Res., 7 [Suppl. 1]:30-35.

Amzica, F. and Steriade, M. (1998) Electrophysiological correlates of sleep delta waves. Electroencephalgr. Clin. Neurophysiol., 107:69-83.

Amzica, F. and Steriade, M. (1998) Cellular substrates and laminar profile of sleep K-complex. Neuroscience, 82:671-686.

Amzica, F. and Steriade, M. (1997) The K-complex: its slow (<1 Hz) rhythmicity and relation with delta waves. Neurology, 49:952-959.

Steriade, M. and Amzica, F. (1996) Intracortical and corticothalamic coherency of fast spontaneous oscillations. Proc. Natl. Acad. Sci. USA, 93:2533-2538.

Steriade, M., Amzica, F. and Contreras, D. (1996) Synchronization of fast (30-40 Hz) spontaneous cortical rhythms during brain arousal. J. Neurosci., 16:392-417.

Amzica, F. and Steriade, M. (1995) Disconnection of intracortical synaptic linkages disrupts synchronization of a slow oscillation. J. Neurosci., 15:4658-4677.

Amzica, F. and Steriade, M. (1995) Short- and long-range synchronization of the slow (<1 Hz) cortical oscillation. J. Neurophysiol., 73:20-38.

Steriade, M. and Amzica, F. (1994) Dynamic coupling among neocortical neurons during evoked and spontaneous spike-wave seizure activity. J. Neurophysiol., 72:2051-2069.

Steriade, M., Contreras, D. and Amzica, F. (1994) Synchronized sleep oscillations and their paroxysmal developments. Trends in Neurosci., 17:199-208.

Steriade, M., Amzica, F. and Contreras, D. (1994) Cortical and thalamic cellular correlates of electroencephalographic burst-suppression. Electroencephalogr. clin. Neurophysiol., 90:1-16.

Steriade, M., Nuñez, A. and Amzica, F. (1993) Intracellular analysis of relations between the slow (<1 Hz) neocortical oscillation and other sleep rhythms of the electroencephalogram. J. Neurosci., 13:3266-3283.

Steriade, M., Nuñez, A. and Amzica, F. (1993) A novel slow oscillation (<1 Hz) of neocortical neurons in vivo: depolarizing and hyperpolarizing components. J. Neurosci., 13:3252-3265.

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